Assessment of Hyperinsulinaemia Serum Fatty Synthase levels and Hypertriglyceridaemia in type 2 Diabetes Mellitus at UTH, Lusaka, Zambia
Date
2015-02-19
Authors
Sinkala, Musalula
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Abstract
Context— The transcriptional regulation of lipogenesis is a highly coordinated
process that is controlled by insulin. Fatty acid synthase (FASN) plays a central role
in de novo lipogenesis by converting acetyl-CoA and malonyl-CoA into the final end
product, palmitate, which may subsequently be esterified into triacylglycerols and
then stored in adipose tissue. Triacylglyceride and other lipids have been implicated
in the development of atherocardiovascular complications in diabetes mellitus.
Aims— In this study we aimed to assess serum insulin and fatty acids synthase in
patients with T2DM and their relationship with hypertriglyceridaemia.
Methods and Results— An analytical cross-sectional study was undertaken in black
indigenous Zambians. Serum insulin, circulating FASN and triglycerides were
assessed in T2DM and non-diabetic participants. Our results showed that
participants with T2DM had significantly higher insulin and FASN levels (p < 0.001
and p = 0.022 respectively). Serum triglycerides were also significantly higher in
diabetics (p = 0.039). Insulin correlated to FASN in non-diabetic participants with
statistical significance (r = 0.476, p = 0.034). Serum insulin also correlated to
circulating FASN in diabetic participants (r = 0.333), however the correlation was not
statistically significant (p = 0.139). Multivariate linear regression showed that
circulating FASN was the best predictor of triglycerides concentration (ß = 0.340, p =
0.09).
Conclusion— The results of this study showed that hyperinsulinaemia and high
FASN are characteristic of T2DM. The existence of high FASN in the presence of
hyperinsulinaemia could explain the hypertriglyceridaemia and the associated
increase in atherocardiovascular complications observed in T2DM.
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Keywords
Hypertriglyceridaemia , Hyperlipemia-diagnosis , Diabetes Mellitus-Complications , Diabetes Mellitus-Therapy