Factors associated with urinary tract infections in patients undergoing transrectal prostate biopsy at adult hospital of the university teaching hospitals, Lusaka, Zambia.
| dc.contributor.author | Malemuna, Nkambo | |
| dc.date.accessioned | 2022-05-20T14:32:17Z | |
| dc.date.available | 2022-05-20T14:32:17Z | |
| dc.date.issued | 2020 | |
| dc.description | Thesis | en |
| dc.description.abstract | Background: Transrectal prostate biopsy is currently the standard technique for obtaining tissue to make a histological diagnosis of prostate cancer. Infectious complications after the procedure can occur despite patients being on antibiotic prophylaxis. These complications range from being mild to severe and life-threatening. Growing evidence attributes this to the increasing resistance to the commonly used antimicrobial agents. The study therefore aimed at evaluating the risk factors of urinary tract infections following prostate biopsy, establishing the pathogens involved and their resistance patterns. Methodology: This was a prospective cross-sectional study of a consecutive cohort of patients who underwent transrectal prostate biopsy at the adult Hospital of the University Teaching Hospitals between September 2019 and February 2020. All patients meeting the inclusion criteria were enrolled, demographic and clinical details were obtained using a questionnaire. Rectal swabs and urine for culture were collected before the procedure. A second urine sample for culture was collected one week after the procedure. Data analysis was conducted using STATA version 13 and results with pvalue less than 0.05 were considered significant. Results: Of the 139 patients who participated in the study, 18 (12.9%) had a urinary tract infection after prostate biopsy. HIV seropositive status was a significant predictor for development of UTI after prostate biopsy. Escherichia coli was the most common pathogen isolated in the rectal swab (63%). In post biopsy urine, Escherichia coli was isolated in 67% (12/18) of patients with UTI. Its resistance to the routinely used antibiotic (Ciprofloxacin) was 83% (10/12) and sensitivity to Fosfomycin and Nitrofurantoin was 100 % and 75% respectively. Conclusion: The prevalence of UTIs after transrectal prostate biopsy was 12.9% and E coli was the main causative organism. HIV seropositive status, history of having been in acute urinary retention and paraplegia were independent predictors of UTI after prostate biopsy. Keywords: pre-biopsy antibiotic prophylaxis, transrectal prostate biopsy, rectal swab, urinary tract infection. | en |
| dc.identifier.uri | http://dspace.unza.zm/handle/123456789/7327 | |
| dc.language.iso | en | en |
| dc.publisher | The University of Zambia | en |
| dc.subject | Urinary tract infections. | en |
| dc.subject | Urinary tract infections--Prostate biopsy. | en |
| dc.subject | Prostate cancer--Histological diagnosis. | en |
| dc.title | Factors associated with urinary tract infections in patients undergoing transrectal prostate biopsy at adult hospital of the university teaching hospitals, Lusaka, Zambia. | en |
| dc.type | Thesis | en |