Show simple item record

dc.contributor.authorZimba, Stanley
dc.date.accessioned2017-12-20T08:56:30Z
dc.date.available2017-12-20T08:56:30Z
dc.date.issued2016
dc.identifier.urihttp://dspace.unza.zm:8080/xmlui/handle/123456789/5065
dc.descriptionTHESIS M.MEDen
dc.description.abstractINTRODUCTION: There has been a substantial and significant increase in patients hospitalized for ischaemic stroke with co-existing HIV infection. Little is known about the mechanism of stroke in these HIV+ve patients as no studies had been done in our region. Elsewhere, attributed mechanisms included vasculitis and hypercoagulability state with protein S deficiency being a prominent feature. Little is also known of the effect of antiretroviral drugs on patients with hypercoagulability state. Hence there is a need for this study to help understand the role of hypercoagulability state in HIV+ve ischaemic stroke patients and consequently help improve their management. METHODOLOGY A matched case control study was conducted in which a total of 52 HIV+ve patients with ischaemic stroke were prospectively compared with control groups for occurrence of protein S, protein C deficiencies, hyperhomocysteinaemia as well as other markers like hypercholesterolaemia and obesity. The control groups comprised an equal number of consecutive matched HIV-ve and HIV+ve patients with and without ischaemic stroke respectively. RESULTS Ischaemic stroke of undetermined aetiology occurred more frequently in HIV+ve compared to HIV-ve patients (p<0.001). In addition, protein S deficiency and Hyperhomocysteinaemia were more prominent in HIV+ve than HIV-ve ischaemic stroke patients (P=0.011). There was no difference in the presence of hyperhomocysteinaemia or protein S deficiency in HIV+ve patients with or without ischaemic stroke. Protein C deficiency was not noted to be significantly different between the cases and the two control arms. CONCLUSION There was a strong association between hypercoagulability state and ischaemic stroke in adult HIV+ve patients with traditional markers like smoking, sedentary lifestyle and obesity noted. Protein S deficiency and hyperhomocysteinaemia are strongly associated with HIV infection, and their presence in HIV+ve ischaemic stroke warrants them to be considered as important serum markers in the prevention of ischaemic strokes in the Zambian HIV+ve population.en
dc.language.isoenen
dc.publisherUniversity of Zambiaen
dc.subjectIschemic Attack, Transient-Therapyen
dc.subjectCerebrovascular Diseaseen
dc.subjectCerebral Ischemiaen
dc.subjectHIV/AIDS Diseaseen
dc.titleThe Association of Hypercoagulability state markers in adult HIV positive patients with Ischaemic stroke at The University Teaching Hospital, Lusaka, Zambiaen
dc.typeThesisen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record