Statistical assessment of cervical squamous cell carcinoma attributable risk to HIV-Infected Women in Zambia
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Cervical cancer is the second most common cancer among women worldwide with estimated 529,409 new cases and 274,883 deaths in 2008, as reported by the International Agency for Research on Cancer. In Zambia, cervical cancer is estimated to be the leading cause of cancer and cancer mortality in women of all ages. Research does seem to indicate that being infected with the human immunodeficiency virus (HIV) increases susceptibility to the most common cancer cell, the squamous cell carcinoma. The magnitude of the risk, however, is unknown for the case of Zambia. To determine the attributable risk of this cell on HIV positive subjects the study utilized a matched case-control design on data from medical records at National Cancer Diseases Hospital (NCDH) in Lusaka for period 2007 to 2010. Medical records of women aged 18 to 59 years old and whose information on age, marital status, HIV status and cancer diagnosis were available constituted the target population. Analysis from a sample of 348 such subjects indicates a significant association between cervical squamous cell carcinoma and HIV, a Chisquare test of one degree yielded a value of 5.63. The risk of having cervical squamous cell carcinoma attributed to HIV was estimated to be 2.1542 times higher for women exposed HIV as compared to those unexposed. The findings showed that HIV-infected women are at higher risk of cervical squamous cell carcinoma than HIV-infected women and there is strong association between CSCC and HIV among women in Zambia.
The University of Zambia
- Natural Sciences