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    Immunohistochemical expression of Vitamin-D Receptor in oral and skin squamous cell carcinoma of a black African Sub-population

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    Medical Journal (3.684Mb)
    Date
    2017
    Author
    Adisa, A.O
    Ogun, G.O
    Udeabor, S.E
    Orlowska, A
    Sader, R.A
    Ghanaati, S
    Type
    Article
    Language
    en
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    Abstract
    The nuclear vitamin D receptor (VDR) is involved in multiple pathways that have a role to play in the biology of cancer. Recent evidence indicates that the active form of vitamin D (1alpha, 25-dihydroxycholecalciferol) (VD) exhibits several anti-growth effects. Thus it is useful as an anti-neoplastic agent in several human malignancies. We aim to analyze the expression of VDR in skin and oral squamous cell carcinomas (skin SCC and OSCC) from a black African sub-population to determine potential for active VD therapy in such patients.Nineteen formalin fixed paraffin embedded (FFPE) blocks of OSCC and 15 Skin SCC FFPE were prepared for Abcam Rabbit polyclonal Anti-Vitamin D Receptor antibody ChIPGrade (ab3508).Nuclear brown staining was considered as positive for VDR. The Sinicrope scoring method was used to evaluate the stained epithelial cells. All slides were viewed with a Nikon ECLIPSE 80i microscope and microphotographs recorded.Among 15 moderately differentiated OSCC 7 (46.7%) showed moderate to strong positivity for VDR, while 8 were weak or negative for VDR. Among 10 well differentiated SCC of the skin, 8 (80%) cases showed moderate to strong VDR positivity, while 2 cases showed weak expression.Overall,approximately the same number of OSCC (9 cases) and Skin SCC (10 cases) expressed moderate to strong positivity for VDR. In our study, we noted that the OSCC and skin SCC have similar number of cases expressing moderate to strong positive staining for VDR. Thus we suggest that the chemotherapeutic role already established for VD is of relevance in OSCC and skin SCC in black Africans.
    URI
    http://dspace.unza.zm/handle/123456789/5160
    Citation
    Adisa, A.O., Ogun, G.O., Udeabor, S.E., Orlowska, A., Sader, R.A., Ghanaati, S. (2017). Immunohistochemical expression of Vitamin-D Receptor in oral and skin squamous cell carcinoma of a black African Sub-population. Medical Journal of Zambian. 44(2)
    Sponsorship
    Office of Global AIDS/US Department of State
    Publisher
    University of Zambia, Medical Library
    Subject
    Immunohistochemical
    Oral and Skin Squamous Cell Carcinoma
    Description
    An analysis of the expression of VDR in skin and oral squamous cell carcinomas (skin SCC and OSCC) from a black African sub-population to determine potential for active VD therapy in such patients.
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