Raised Levels: A Risk Factor for Cardiovascular Associated Complications in HIV Positive Zambians before Initiation of Antiretroviral Therapy
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The objectives of the study were to compare plasma levels of IL-6 in HIV positive and HIV negative individuals and to correlate them with CD4 count Materials and methods: A cross-sectional study was carried out at the University Teaching Hospital in Lusaka, Zambia. IL-6 and CD4 were assessed in HIV positive on ART, HIV positive ART- naïve and HIV negative control participants. Results and Conclusion: Our study showed that HIV ART naïve participants had higher IL-6 concentrations (2.83 ± 1.60 ng/ml) than those on ART (2.49 ± 1.21 ng/ml) p = 0.020. HIV negative control participants however, had higher concentrations of IL-6 (3.24 ± 1.33 ng/ml) than HIV positive participants on ART (2.49 ± 1.21) p = 0.002. HIV positive ART naïve individuals therefore, had the highest IL-6 levels. The results also showed that ART lowers inflammation in HIV and this may explain why ART reduces the risk of developing opportunistic tumours and other infections in HIV .
CitationMantina, F.H., Mwaba, F., Sinkala, M., Kwenda, G., Kaile, T. and Nhhoma, P. (2017). Raised Levels: A Risk Factor for Cardiovascular Associated Complications in HIV Positive Zambians before Initiation of Antiretroviral Therapy. Medical Journal of Zambia. 44 (2)
SponsorshipOffice of Global AIDS/US Department of State.
University of Zambia, Medical Library
Heart Diseases--HIV Infections--Zambia
Plasma levels of IL-6 in HIV positive and HIV negative individuals and to correlated with CD4 count
- Ministry of Health