Glucose-6-phosphate dehydrogenase deficiency: Screening of 200 Zambian new born
Date
1984-06
Authors
Bhagwat, G. P.
Mwisiya, M.
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Journal of Zambia.
Abstract
Two hundred newborn children were studied for the frequency of occurrence of glucose-6 phosphate dehydrogenase (G-6-PD) deficiency at University Teaching Hospital, Lusaka. An overall frequency of 11.5 percent was observed. Of the 102 males 13.7 percent were deficient and amongst 98 females 9.1 % showed deficiency. A high incidence of deficiency was observed in. people of the Nsenga (22.5%) and Ngoni (18.7%) tribes whereas the Chewa and Bemba tribes had a low incidence (less than 6°/o).
Introduction Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency occurs world wide. Its incidence and clinical presentation vary considerably among different ethnic groups. It may express itself as drug-induced haemolvtic anaemia, neonatal jaundice, haemolytic anaemia following infection, chronic non-spherocytic haemolytic anaemia, or favism or it may be asymptomatic (WHO, 1967). The deficiency has been studied extensively in West Africa (Gilles and Taylor, 1961; AIIison et al.,1961), Congo (Sonnet and Michaux,1960) and East Africa (AIlison,1900). There are few reports from the Southern part of Africa. Bernstein, in 1963 reported an incidence of 5-23% in South African Bantus. When WHO (1967) published its report on G-6-PD deficiency in various parts of the world. information from Zambia was non existent. In 1970, Barclay et al for the first time reported an incidence of 17.9% in .Zambia. The present study was undertaken with a view of further documenting the frequency of occurrence of G-6-PD deficiency in the population and in various tribes in Zambia.
Description
Glucose-6 phosphate dehydrogenase (G-6-PD) deficiency in Zambia
Keywords
Dehydration , Glucose dehydration--Zambia , glucose-6 phosphate--Zambia
Citation
Bhagwat, G. P. and Mwisiya, M. (1984). Glucose-6-phosphate dehydrogenase deficiency: Screening of 200 Zambian Newborn. Medical journal of Zambia. Vol. 18 no. 2