• Login
    View Item 
    •   UNZA Repository Home
    • Veterinary Medicine
    • Disease Control
    • View Item
    •   UNZA Repository Home
    • Veterinary Medicine
    • Disease Control
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

    Thumbnail
    View/Open
    Article (1.645Mb)
    Date
    2017
    Author
    Ponte-Sucre, Alicia
    Gamarro, Francisco
    Dujardin, Jean-Claude
    Barrett, Michael P.
    Lo pez-VeÂlez, Rogelio
    GarcõÂa-HernaÂndez, Raquel
    Pountain, Andrew W
    Papadopoulou, Barbara
    Mwenechanya, Roy
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e.g., in North Bihar in India. In this review, we discuss the meaning of ªresistanceº related to leishmaniasis and discuss its molecular epidemiology, particularly for Leishmania donovani that causes visceral leishmaniasis. We also discuss how resistance can affect drug combination therapies. Molecular mechanisms known to contribute to resistance to antimonials, amphotericin B, and miltefosine are also outlined.
    URI
    http://dspace.unza.zm/handle/123456789/5771
    Publisher
    PLOS Neglected Tropical Diseases
    Subject
    Chemotherapy
    Leishmaniasts
    Description
    Journal article
    Collections
    • Disease Control [10]

    DSpace software copyright © 2002-2016  DuraSpace
    UNZA homepage | UNZA Library | Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of UNZA RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    UNZA homepage | UNZA Library | Contact Us | Send Feedback
    Theme by 
    Atmire NV