Cushing's syndrome associated with thymic tumour in a 32 year old Zambian African female
Date
1976-06
Authors
Mpofu, P.
Amin, EI A. M.
Nyelesani, E. K.
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Journal of Zambia
Abstract
As early as 1928 Brown noticed the association of Cushing's Syndrome with Bronchial Carcinoma.Since then, similar cases have been recorded by different authors with increasing frequency. Biochemical and bioassay techniques have left little doubt that under these circumstances the adrenal hypersecretion responsible for the Gushing Syndrome is the result of stimulation of Adrenocorticotrophin (ACTH) or by an adrenocorticotrophin-like hormone elaborated by the malignant cells themselves. Recently,
extra-adrenal carcinomas, especially those arising from thymus, the ovaries and the pancreas have been shown to produce similar adrenal hyperactivity with overt
clinical and biochemical Cushing's Syndrome. To the
best of our knowledge, however, none of these conditions
have been described in the Southern African
or Zambian Medical Literature.
Description
Cushing's Syndrome with Bronchial Carcinoma.
Keywords
Thymic Tumour , Bronchial Carcinoma , Adrenalectomy
Citation
Mpofu, P., Amin, EI A. M. and Nyelesani, E. K. (1976). Cushing's syndrome associated with thymic tumour in a 32 year old Zambian African female. Medical Journal of Zambia. 10, (3)