Seroprevalence of parvovirus B19 in blood donors at the Kitwe Central Hospital, Blood Bank, Kitwe, Zambia
Date
2018
Authors
Kalolekesha, Memory Chirambo
Journal Title
Journal ISSN
Volume Title
Publisher
The University of Zambia
Abstract
Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus
which is pathogenic to humans causing a wide array of clinical complications
which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is
generally harmless in healthy individuals but may be life threatening in
immunocompromised individuals such as patients with sickle cell disease and
pregnant women. It has been shown to be transmissible by blood transfusion but
donor screening for the virus is not yet mandatory in most sub-saharan African
countries including Zambia.
This was a cross sectional study which aimed to determine the seroprevalence of
Parvovirus B19 infections among healthy blood donors at the Kitwe Central
Hospital, Blood Bank. The specific objectives were to detect Parvovirus B19 IgM
antibodies in donor blood using serology and to analyse the age and sex
distribution of parvovirus among blood donors.
The net prevalence of parvovirus B19 IgM in this study was 15.6%. The majority
of the positive cases were in the age group 15-22 years(17.8%) but there was no
statistical significance between occurrence of parvovirus and age (p value=0.756).
Prevalence in males was higher than in females i.e. 16.4% and 13.8%,
respectively. The relationship between gender and parvovirus B19 occurrence
was however not significant either (p value=0.646).
Description
Thesis
Keywords
Human parvovirus -- Zambia , Blood donations--Zambia