• Login
    View Item 
    •   UNZA Repository Home
    • Theses and Dissertations
    • Medicine
    • View Item
    •   UNZA Repository Home
    • Theses and Dissertations
    • Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Therapeutic outcomes in aids-associated kaposi's sarcoma patients on antiretroviral therapy treated with chemotherapy at University Teaching Hospital and cancer diseases hospital in Lusaka, Zambia

    Thumbnail
    View/Open
    Main Document.pdf (2.576Mb)
    Date
    2019
    Author
    Mtonga, Watson
    Type
    Thesis
    Language
    en
    Metadata
    Show full item record

    Abstract
    The incidence of HIV-associated Kaposi’s sarcoma remains high in Zambia in the antiretroviral therapy era. The most efficacious treatment regimen for KS has yet to be established. In both developed and developing countries, treatment regimens have had limited efficacy. Late presentation in Africa affects therapeutic outcomes. The aim of this study was to determine the therapeutic outcomes of epidemic KS patients after completion of six cycles of Adriamycin, Bleomycin, and Vincristine (ABV) chemotherapy. This was a descriptive cross-sectional study. Study participants were drawn from a study database of confirmed incident KS patients seen at the Skin Clinic of the University Teaching Hospitals (UTH) during the period between August, 2015 and September, 2016. Of the 38 successfully recruited study participants, a complete response was documented in 18 (47.4%) after 6 cycles of ABV whereas 20 (52.6%) experienced a partial response. KS recurrence was observed in 8 (44.4%) of individuals that experienced an initial complete response. At the time of the study, clinical assessment revealed that KS lesions had completely regressed in 21 (55.3%) of all the patients. ABV chemotherapy appears ineffective in long-term resolution of epidemic KS patients on ART. Recurrence rates are high after chemotherapy in patients that experience initially favorable responses to treatment. There is a need to diagnose KS earlier, and to develop more efficacious treatment options in order to reduce recurrence rates for epidemic KS. Key words: Kaposi’s Sarcoma, HIV-associated, treatment, chemotherapy, outcomes, recurrence.
    URI
    http://dspace.unza.zm/handle/123456789/6913
    Publisher
    The University of Zambia
    Subject
    Kaposi’s Sarcoma-- HIV associated treatment--Zambia
    Kaposi’s sarcoma--Treatment
    HIV--Treatment
    Description
    Thesis
    Collections
    • Medicine [915]

    DSpace software copyright © 2002-2016  DuraSpace
    UNZA homepage | UNZA Library | Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of UNZA RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    UNZA homepage | UNZA Library | Contact Us | Send Feedback
    Theme by 
    Atmire NV