Medical Theses and Dissertations

Permanent URI for this collection

http://41.63.25.24:4000/handle/123456789/6021

Browse

Browsing Medical Theses and Dissertations by Subject "Abortion--Treatment--Zambia"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    A Study of the safety,Effectiveness,and Acceptability of Misprostol for Treatment of Incomplet Abortion at the University Teaching Hospital,Lusaka,Zambia
    (2012-01-12) Mupeta, Stephen
    Incomplete abortion is a major cause of morbidity and mortality among women that experience an abortion. The treatment for incomplete abortion at the University Teaching Hospital (UTH) is currently manual vacuum aspiration (MVA). Misoprostol, a prostaglandin E1 analogue, is a medical alternative to surgical means for treatment of incomplete abortion. This is because of ease of use, less complications, high patient satisfaction and potential use by a wide range of providers in various health care set-ups.In this study 600μg oral dose of misoprostol was used to evaluate the safety, effectiveness and acceptability of this drug for treatment of incomplete abortion at the University Teaching Hospital in Zambia. An open label, single arm prospective study design was employed to recruit 152 patients presenting at Lusaka’s University Teaching Hospital Gynecological gynecology emergency ward for treatment of incomplete abortion with pregnancies in the first trimester between 31st October and 30th November 2009.Data collected was on the participants’ demographics, obstetrics and gynecological history including previous abortions and contraceptive use. Pre and post intervention questionnaires were administered to collect the data.The primary measure of effectiveness was complete uterine evacuation without recourse to additional surgical intervention at any point for any reason. Other outcome measures included side effects, acceptability and satisfaction.As the study assessed women’s satisfaction with and acceptability of the treatment, each participant was asked to grade their satisfaction with the method on a scale of 4 and to indicate whether she would select the treatment again, and if she would recommend it to a another person. Vaginal bleeding, Abdominal cramping, incidence of infection were used to measure the safety of the intervention. Abdominal cramps and vaginal bleeding were graded regarding severity whilst infection was based on symptoms and signs that could indicative.The study showed a success rate of 95.7%, satisfaction and acceptability of about 99%. The study did not record any unexpected side effects and no patient experienced serious adverse events. The mean age of participants was 26.1, most were married (65.8%), majority of them having been only up to secondary school (38.8% senior and 30.3%Junior secondary). Most of the women were in their 2nd to 4th pregnancy (59.9%) with mean gestational age being 9 weeks. Majority reported the abortion to have been spontaneous (86.8%). Fifty percent (50%) of the participants reported having used a form of contractive method before and about 20% of participants reported falling pregnant whilst on a contraceptive method. Forty eight percent (48%) of the participants reported pregnancies being diagnosed by symptoms alone (no pregnancy test or ultrasound scan done). Almost all the participants in the study were referred from a health center.The study demonstrated that oral 600μg misoprostol is a safe, effective and acceptable alternative for the treatment of incomplete abortion at the University Teaching Hospital in Lusaka.